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ta65

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on November 17, 2011 at 3:51:07 pm
 

DIYgenomics - TA-65 Telomere Length and Telomerase Activation Study

Back to DIYgenomics.org

 

Commercial telomere length testing

Legend: Company, Testing Method, What is actually "tested," Cost of Test, Validation Studies

  • Repeat Diagnostics, Multicolor Flow FISH (Florescense in-situ hybridization), mean telomere length $400 - basic test, yes - more, Maryland (autoflorescence
  • WBC type-specific telomere length accurate (i.e., lymphocytes, granulocytes, $800 - for detailed  than Southern naive T cells, memory T-cells test with naive T cells blot, PCR NK cells) memory T cells, NK & Q-FISH cells
  • SpectraCell Quantitative Real time  Average telomere length of, $350 yes - mostly w/ Houston, TX PCR WBCs in 1cc of blood - not TA Sciences, WBC type-specific
  • Life Length, HT Q-FISH + Shortest telomere length, 500 Euros, no Telomapping of peripheral blood WBCs and peripheral blood mononuclear cells (stem cells)

 

Telomerase activation supplements

 

Company Product Names Active Ingredients Potency (scale: 1-100)*
Cost Validation Studies

a. TA Sciences TA-65 Cycloastregenol 5mg 1.5 $600/90 capsules yes
         250 units/capsule (= 5mg) = $200-800/month
dose recommendation:  = $2,400- 8,000/year
1, 2, or 4 capsules/day

b. Sierra Sciences Product B 28 botanicals (see below)   30
$77-99/120 capsules yes, but I have not
     (sold by Isagenix)        Vit. C 20mg = $77-99/month    seen them
Reno, NV Vit E 15 IU = $1,000-1,200/yr    published
Vit B12  20mcg
Proprietary blend 910 mg
dose recommendation:
4 capsules/day

c. Astraglaxo Astragaloside IV Astragaloside IV - 40mg or 50mg    ?
unknown  $ no
China Cycloastragenol Cycloastragenol- 5mg, 10mg, 25 mg, or 50 mg
recommended dosages:
Astragaloside IV - 50-100mg/day
Cycloastragenol - 2-4 capsules/day

c. Medicinal Maximum Astralagoside IV 40mg ? $72/60 capsules no
      Nutraceuticals Telomere Vit D 2,000 IU = $36-72/month
      Henderson, NV Support dose recommendation: = $440-900/yr
1-2 capsules/day

d. Advantage Impex Co     HTA98 Cycloastregenol 5mg, 10mg ? 100-140
L/30 capsules
     United Kingdom recommended dosage: = 100-280 L/month
1-2 capsules/day

e. Telomere Biosciences Telomere 5 Telomerase activators **      ?
unknown $ no
      Chappaqua, NY Length Vit C 540 mg
Complex w/ Vit D3 600 IU
T-Activator 100 Vit E 310 IU
Folate 400 mcg

**Potency:  This is a scale that Bill Andrews came up with.  100 is
the level of Telomerase activity in a Hela Cell (immortal cell line)
     10 would be 10% of the telomerase activity in a Hela Cell
This needs to be done by an independent lab with "head-to-head"
testing, which has NOT been done!

**Ingredients in Telomere BioSciences "Telomere Length Complex"

1. L-Arginine
2. Fo-Ti Root
3. L-Citrulline
4. Rehmanna Root
5. Ligusticum Berry
6. Astralagus Root Extract
7. Grape seed Extract
8. Vit C - 540 mg
9. Vit D3 600 IU
10. Vit E 310 IU
11. Folate 400 mcg

 

Potential funding sources

 

 

Confirm immunology protocol and recruit immunology advisors

  • Key questions
    • Is this the correct protocol (positive structure/function), what is missing, what would be logically measured
    • Effect was most pronounced in CMV+ individuals
  • Contacts
    • Monica Ranes-Goldberg, Immunology Professor, UCSC (8/3, call 8/10)
    • Daniel Kraft, Stanford Stem Cell Research (8/3)
    • Mark Hamalainen, Halcyon Molecular (8/3)
    • Mark M Davis, Dir Stanford Inst for Immunology
    • Chris Hogg, Gilean (8/3, no immediate contacts)
  • Cancer and telomere contacts

 

2. Recruit CROs


3. Determine IRB (Institutional Review Board) strategy, informed consent, regulatory concerns, ethics, etc.

 

4. Recruit and confirm oncology contacts

 

5. Develop protocol

  • Locate templates and/or examples of other study protocols
    • Cancer immunology trials from www.clinicaltrials.gov,
    • Identify relevant categories
      • Purpose
      • Function
      • Rationale
      • Design
      • Participants
      • Intervention
      • Demographics
      • Design
      • Endpoints
    • Complete protocol draft

 

6. Budget

  • Intervention - TA-65
  • Testing - blood sample collection and shipping, UCLA immunology tests, TelomeHealth critically-short telomere-length testing and storage, 23andMe genotyping
  • Staff time - study planning, administration
  • Publication cost (if open-access journal selected (PLoSOne $1350, JMIR $1900)

 

Background information

 

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