DIYgenomics wiki homepage
Title and Genomera Study Page: CILTEP Nootropics Smart Drug Genomics Study
Summary: This study investigates whether genetic predisposition may be implicated in the effectiveness of nootropic smart drugs like CILTEP. This study is overseen by the Rikengenesis IRB (Institutional Review Board).
Hypothesis: Individuals with polymorphisms in genes related to nootropic targeting and processing may be more likely to benefit from them.
Study conduct: The study is conducted in two parts that examine genetic profile and phenotypic response.
Genetic Analysis through Personal Genome Files
Function | Gene | SNP | Alleles | Note | |
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Citation | Link | |
L-theanine & caffeine | CYP1A2 | rs762551 | C | A | |
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Cornelis 2006 | http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=16522833 |
L-theanine & caffeine | |
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fast/slow caffeine metabolizer; A fast metab; C slow |
long-term potentiation | |
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episodic memory performance | KIBRA | rs17070145 | C | T | T = favorable | |
Franks 2014 | http://www.ncbi.nlm.nih.gov/pubmed/25339899 | |
episodic memory performance | |
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http://www.snpedia.com/index.php/Rs17070145 |
GABA, Neuroplastins Np65 and Np55 | NPTN | rs7171755 | A | G | G = favorable | |
Desrivières 2014 | http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2013197a.html | |
GABA, Neuroplastins Np65 and Np55 | |
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Beesley 2014 | http://www.ncbi.nlm.nih.gov/pubmed/25300133 |
Bioflavanoid processing | CYP1A1 2A | rs4646903 | A | C | |
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Hamachi 2013 | http://www.ncbi.nlm.nih.gov/pubmed/23840148 |
Bioflavanoid processing | CYP1A1 2C | rs1048943 | A | G | |
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Hamachi 2013 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677005/ |
Bioflavanoid processing | NQO1 C609T | rs1800566 | C | T | |
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Hamachi 2013 | |
Bioflavanoid processing | GSTM1 | rs4147565 | G | A | |
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Agúndez JA | http://www.ncbi.nlm.nih.gov/pubmed/18303971?dopt=Abstract |
mucopolysaccharidosis | GUSB | rs9530 | C | T | |
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http://www.jci.org/articles/view/72339 |
mucopolysaccharidosis | |
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https://www.google.com/search?q=snpedia+gusb; http://en.wikipedia.org/wiki/GUSB |
Klotho | KL C1548T | no rs # | T | C | |
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Kim 2014 | http://www.ncbi.nlm.nih.gov/pubmed/25120167 |
Klotho | KL | rs9536314 | T | G | G = favorable | in 23 | Dubal 2014 | http://www.cell.com/cell-reports/fulltext/S2211-1247%2814%2900287-3 | |
Klotho | KL | rs9527025 | G | C | C = favorable | n/a 23 | Dubal 2014 | |
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Tyrosine hydroxylase | TH | rs10770141 | C | T | T = favorable | |
Horiguchi 2014 | http://www.ncbi.nlm.nih.gov/pubmed/24417771 | |
Tyrosine hydroxylase | |
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http://circ.ahajournals.org/content/116/9/993.full |
UDP-Glucuronosyltransferase | UGT | rs8330 | C | G | |
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Court 2013 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629801/ |
bilirubin level influencer | UGT1A1 | rs887829 | A | G | |
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Chen 2012 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306855/ |
phenobarbital response enhancer module | UGT1A1 | rs10929302 | G | A | |
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Chen 2012 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306855/ |
bioavailability of luteolin (a flavone, a type of flavonoid) | |
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Lin 2008 | http://www.ncbi.nlm.nih.gov/pubmed/18991571 | |
beta glucuronidase activity | UGT1A3 | rs3806596 | n/a 23andMe | |
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Santoro 2014 | http://onlinelibrary.wiley.com/doi/10.1111/bcp.12437/abstract | ||
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UGT1A3 | rs1983023 | n/a 23andMe | |
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UGT1A3 | A17G, Q6R; | what rs SNPs? | |
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Chen 2006 | http://www.ncbi.nlm.nih.gov/pubmed/16738032 | ||
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UGT1A3 | T31C, W11R; | what rs SNPs? | |
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flavonoids: quercetin, luteolin, and kaempferol | ||
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UGT1A3 | C133T, R45W; and | what rs SNPs? | |
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UGT1A3 | T140C, V47A | what rs SNPs? | |
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Dopamine SNPs | COMT Val158met | rs4680 | A | G | |
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Mitaki 2013 | http://www.ncbi.nlm.nih.gov/pubmed/22530780 |
Luteolin is a substrate of COMT | DR 4 (DRD4) | rs1800955 | C | T | |
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He 2012 | http://www.nature.com/srep/2012/120920/srep00677/full/srep00677.html |
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DRD2 | rs1076560 | C | A | |
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Wang 2013 | http://www.ncbi.nlm.nih.gov/pubmed/23421762 |
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Clarke 2013 | http://onlinelibrary.wiley.com/doi/10.1111/ahg.12046/abstract |
Renin-angiotensin-aldosterone | |
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Aldosterone | CYP11B2 | rs1799998 | A | G | higher risk for G carriers | Jia 2012 | http://www.ncbi.nlm.nih.gov/pubmed/22508051?dopt=Abstract | ||
Angiotensin-converting enzyme | ACE | rs4343 | G | A | |
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Angiotensin | AGTR1 | rs5182 | A | C | |
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Angiotensin | AGTR1 | rs5182 | C | T | |
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Aldosterone synthase (CYP11B2)- 344 C/T polymorphism |
Angiotensin | AGT | rs5049 | G | A | |
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Angiotensin | AGT | rs5051 | G | A | |
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Angiotensin | AGT | rs699 | T | C | |
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Angiotensin | AGT | rs4762 | C | T | |
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PDE4/Adenylate cyclase | PDE4D | rs1588265 | A | G | Apuhan 2013 |
http://www.ncbi.nlm.nih.gov/pubmed/24142618 |
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PDE4/Adenylate cyclase | ADRB2 | rs1042713 | G | A | Eyler 2008; Kim 2011 |
http://www.ncbi.nlm.nih.gov/pubmed/18324973; http://www.ncbi.nlm.nih.gov/pubmed/21545619 |
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PDE4/Adenylate cyclase | ADCY6 | rs3730070 | G | C | Eyler 2008 | http://www.ncbi.nlm.nih.gov/pubmed/18324973 | |||
PDE4/Adenylate cyclase | ADCY6 | rs3730071 | G | A/C | Eyler 2008 | http://www.ncbi.nlm.nih.gov/pubmed/18324973 | |||
PDE4/Adenylate cyclase | ADCY6 | rs7300155 | G | A | Eyler 2008 | http://www.ncbi.nlm.nih.gov/pubmed/18324973 | |||
PDE4/Adenylate cyclase | ADCY9 | rs2230739 | A | G | Kim 2011 | http://www.ncbi.nlm.nih.gov/pubmed/21545619 |