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DIYgenomics CILTEP Nootropics Smart Drug Genomics Study

DIYgenomics wiki homepage


Title and Genomera Study Page: CILTEP Nootropics Smart Drug Genomics Study


Summary: This study investigates whether genetic predisposition may be implicated in the effectiveness of nootropic smart drugs like CILTEP. This study is overseen by the Rikengenesis IRB (Institutional Review Board).


Hypothesis: Individuals with polymorphisms in genes related to nootropic targeting and processing may be more likely to benefit from them.


Study conduct: The study is conducted in two parts that examine genetic profile and phenotypic response.


Genetic Analysis through Personal Genome Files

Function Gene SNP Alleles Note  
Citation Link
L-theanine & caffeine CYP1A2 rs762551 C A  
Cornelis 2006 http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=16522833
L-theanine & caffeine  
fast/slow caffeine metabolizer; A fast metab; C slow
long-term potentiation  
episodic memory performance KIBRA rs17070145 C T T = favorable  
Franks 2014 http://www.ncbi.nlm.nih.gov/pubmed/25339899
episodic memory performance  
GABA, Neuroplastins Np65 and Np55  NPTN rs7171755 A G G = favorable  
Desrivières ‎2014 http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2013197a.html
GABA, Neuroplastins Np65 and Np55   
Beesley 2014 http://www.ncbi.nlm.nih.gov/pubmed/25300133
Bioflavanoid processing CYP1A1 2A  rs4646903 A C  
Hamachi 2013 http://www.ncbi.nlm.nih.gov/pubmed/23840148
Bioflavanoid processing CYP1A1 2C  rs1048943 A G  
Hamachi 2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677005/
Bioflavanoid processing NQO1 C609T rs1800566 C T  
Hamachi 2013  
Bioflavanoid processing GSTM1 rs4147565 G A  
Agúndez JA http://www.ncbi.nlm.nih.gov/pubmed/18303971?dopt=Abstract
 mucopolysaccharidosis GUSB rs9530 C T  
https://www.google.com/search?q=snpedia+gusb; http://en.wikipedia.org/wiki/GUSB
Klotho KL C1548T  no rs # T C  
Kim 2014 http://www.ncbi.nlm.nih.gov/pubmed/25120167
Klotho KL rs9536314 T G G = favorable in 23 Dubal 2014 http://www.cell.com/cell-reports/fulltext/S2211-1247%2814%2900287-3
Klotho KL rs9527025 G C C = favorable n/a 23 Dubal 2014  
Tyrosine hydroxylase  TH rs10770141 C T T = favorable  
Horiguchi 2014 http://www.ncbi.nlm.nih.gov/pubmed/24417771
Tyrosine hydroxylase   
UDP-Glucuronosyltransferase UGT rs8330 C G  
Court 2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629801/
bilirubin level influencer UGT1A1 rs887829 A G  
Chen 2012 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306855/
phenobarbital response enhancer module UGT1A1 rs10929302  G A  
Chen 2012 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306855/
bioavailability of luteolin  (a flavone, a type of flavonoid)  
Lin 2008 http://www.ncbi.nlm.nih.gov/pubmed/18991571
beta glucuronidase activity UGT1A3 rs3806596  n/a 23andMe  
Santoro 2014 http://onlinelibrary.wiley.com/doi/10.1111/bcp.12437/abstract
UGT1A3 rs1983023 n/a 23andMe  
UGT1A3 A17G, Q6R;  what rs SNPs?  
Chen 2006 http://www.ncbi.nlm.nih.gov/pubmed/16738032
UGT1A3 T31C, W11R;  what rs SNPs?  
flavonoids: quercetin, luteolin, and kaempferol
UGT1A3 C133T, R45W; and  what rs SNPs?  
UGT1A3 T140C, V47A what rs SNPs?  
Dopamine SNPs COMT Val158met rs4680 A G  
Mitaki 2013 http://www.ncbi.nlm.nih.gov/pubmed/22530780
Luteolin is a substrate of COMT DR 4 (DRD4) rs1800955 C T  
He 2012 http://www.nature.com/srep/2012/120920/srep00677/full/srep00677.html
DRD2 rs1076560 C A  
Wang 2013 http://www.ncbi.nlm.nih.gov/pubmed/23421762
Clarke 2013 http://onlinelibrary.wiley.com/doi/10.1111/ahg.12046/abstract
Aldosterone CYP11B2 rs1799998 A G higher risk for G carriers Jia 2012 http://www.ncbi.nlm.nih.gov/pubmed/22508051?dopt=Abstract
Angiotensin-converting enzyme ACE rs4343 G A  
Angiotensin AGTR1 rs5182 A C  
Angiotensin AGTR1 rs5182 C T  
Aldosterone synthase (CYP11B2)- 344 C/T polymorphism
Angiotensin AGT rs5049 G A  
Angiotensin AGT rs5051 G A  
Angiotensin AGT rs699 T C  
Angiotensin AGT rs4762 C T  


PDE4/Adenylate cyclase PDE4D rs1588265 A G       Apuhan 2013
PDE4/Adenylate cyclase ADRB2 rs1042713 G A       Eyler 2008; Kim 2011

http://www.ncbi.nlm.nih.gov/pubmed/18324973; http://www.ncbi.nlm.nih.gov/pubmed/21545619

PDE4/Adenylate cyclase ADCY6 rs3730070 G C       Eyler 2008 http://www.ncbi.nlm.nih.gov/pubmed/18324973
PDE4/Adenylate cyclase ADCY6 rs3730071 G A/C       Eyler 2008 http://www.ncbi.nlm.nih.gov/pubmed/18324973
PDE4/Adenylate cyclase ADCY6 rs7300155 G A       Eyler 2008 http://www.ncbi.nlm.nih.gov/pubmed/18324973
PDE4/Adenylate cyclase ADCY9 rs2230739 A G       Kim 2011 http://www.ncbi.nlm.nih.gov/pubmed/21545619



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