DIYgenomics - TA-65 Telomere Length and Telomerase Activation Study
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Commercial telomere length testing services (Company, cost, testing method, what is tested)
- Repeat Diagnostics (Vancouver Canada), $400 or $800, Multicolor Flow FISH (Florescense in-situ hybridization), mean telomere length, $400 - basic test, Maryland (autoflorescence WBC type-specific telomere length accurate (i.e., lymphocytes, granulocytes), $800 - detailed test (Southern naive T cells, memory T-cells test with naive T cells blot, PCR NK cells) memory T cells, NK & Q-FISH cells)
- SpectraCell (Houston TX), $350, Quantitative real-time analysis, average telomere length, PCR WBCs in 1cc of blood
- Life Length (Madrid Spain), €500, HT Q-FISH + Shortest telomere length, no Telomapping of peripheral blood WBCs and peripheral blood mononuclear cells (stem cells)
- Titanovo (Patchogue, NY), $99
Telomerase activation supplements (from GRG aging email list post)
- TA Sciences TA-65 Cycloastregenol 5mg 1.5 $600/90 capsules yes, 250 units/capsule (= 5mg) = $200-800/month dose recommendation: = $2,400- 8,000/year, 1, 2, or 4 capsules/day
- Sierra Sciences Product B 28 botanicals (see below) 30, $77-99/120 capsules yes, but I have not, (sold by Isagenix) Vit. C 20mg = $77-99/month, Reno, NV, Vit E 15 IU = $1,000-1,200/yr, published Vit B12 20mcg, Proprietary blend 910 mg, dose recommendation: 4 capsules/day
- Astraglaxo Astragaloside IV Astragaloside IV - 40mg or 50mg, unknown $ no, China Cycloastragenol Cycloastragenol- 5mg, 10mg, 25 mg, or 50 mg, recommended dosages: Astragaloside IV - 50-100mg/day, Cycloastragenol - 2-4 capsules/day
- Medicinal Nutraceutics Medicinal Maximum Astralagoside IV 40mg ? $72/60 capsules no, Nutraceuticals Telomere Vit D 2,000 IU = $36-72/month, Henderson, NV Support dose recommendation: = $440-900/yr, 1-2 capsules/day
- Mackenzie Protocol, Advantage Impex Co, HTA98 Cycloastregenol 5mg, 10mg ? 100-140, L/30 capsules, United Kingdom recommended dosage: = 100-280 L/month, 1-2 capsules/day
- Telomere Biosciences Telomere 5 Telomerase activators, unknown $ no, Chappaqua, NY Length Vit C 540 mg, Complex w/ Vit D3 600 IU, T-Activator 100 Vit E 310 IU, Folate 400 mcg (Ingredients in Telomere BioSciences "Telomere Length Complex": L-Arginine, Fo-Ti Root, L-Citrulline, Rehmanna Root, Ligusticum Berry, Astralagus Root Extract, Grape seed Extract, Vit C - 540 mg, Vit D3 600 IU, Vit E 310 IU, Folate 400 mcg)
Potential study funding sources
Immunology advisors (subject matter experts)
- Protocol confirmation: Correct protocol (positive structure/function), what is missing, what would be logically measured; effect was most pronounced in CMV+ individuals
- Contacts
- Monica Ranes-Goldberg, Immunology Professor, UCSC (8/3, call 8/10)
- Daniel Kraft, Stanford Stem Cell Research (8/3)
- Mark Hamalainen, Halcyon Molecular (8/3)
- Mark M Davis, Dir Stanford Inst for Immunology
- Chris Hogg, Gilean (8/3, no immediate contacts)
- Cancer and telomere contacts
CROs
IRB (Institutional Review Board) strategy, informed consent, regulatory concerns, ethics, etc.
Oncology contacts
Protocol development
- Locate templates and/or examples of other study protocols
- Cancer immunology trials from www.clinicaltrials.gov,
- Identify relevant categories
- Purpose
- Function
- Rationale
- Design
- Participants
- Intervention
- Demographics
- Design
- Endpoints
- Complete protocol draft
Budget
- Intervention - TA-65
- Testing - blood sample collection and shipping, UCLA immunology tests, TelomeHealth critically-short telomere-length testing and storage, 23andMe genotyping
- Staff time - study planning, administration
- Publication cost (if open-access journal selected (PLoSOne $1350, JMIR $1900)
Background articles