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DIYgenomics - TA-65 Telomere Length and Telomerase Activation Study

DIYgenomics wiki homepage

Commercial telomere length testing services (Company, cost, testing method, what is tested)

Repeat Diagnostics (Vancouver Canada), $400 or $800, Multicolor Flow FISH (Florescense in-situ hybridization), mean telomere length, $400 - basic test, Maryland (autoflorescence WBC type-specific telomere length accurate (i.e., lymphocytes, granulocytes), $800 - detailed test (Southern naive T cells, memory T-cells test with naive T cells blot, PCR NK cells) memory T cells, NK & Q-FISH cells)
SpectraCell (Houston TX), $350, Quantitative real-time analysis, average telomere length, PCR WBCs in 1cc of blood
Life Length (Madrid Spain), €500, HT Q-FISH + Shortest telomere length, no Telomapping of peripheral blood WBCs and peripheral blood mononuclear cells (stem cells)
Titanovo (Patchogue, NY), $99

Telomerase activation supplements (from GRG aging email list post)

TA Sciences TA-65 Cycloastregenol 5mg 1.5 $600/90 capsules yes, 250 units/capsule (= 5mg) = $200-800/month dose recommendation: = $2,400- 8,000/year, 1, 2, or 4 capsules/day
Sierra Sciences Product B 28 botanicals (see below) 30, $77-99/120 capsules yes, but I have not, (sold by Isagenix) Vit. C 20mg = $77-99/month, Reno, NV, Vit E 15 IU = $1,000-1,200/yr, published Vit B12 20mcg, Proprietary blend 910 mg, dose recommendation: 4 capsules/day
Astraglaxo Astragaloside IV Astragaloside IV - 40mg or 50mg, unknown $ no, China Cycloastragenol Cycloastragenol- 5mg, 10mg, 25 mg, or 50 mg, recommended dosages: Astragaloside IV - 50-100mg/day, Cycloastragenol - 2-4 capsules/day
Medicinal Nutraceutics Medicinal Maximum Astralagoside IV 40mg ? $72/60 capsules no, Nutraceuticals Telomere Vit D 2,000 IU = $36-72/month, Henderson, NV Support dose recommendation: = $440-900/yr, 1-2 capsules/day
Mackenzie Protocol, Advantage Impex Co, HTA98 Cycloastregenol 5mg, 10mg ? 100-140, L/30 capsules, United Kingdom recommended dosage: = 100-280 L/month, 1-2 capsules/day
Telomere Biosciences Telomere 5 Telomerase activators, unknown $ no, Chappaqua, NY Length Vit C 540 mg, Complex w/ Vit D3 600 IU, T-Activator 100 Vit E 310 IU, Folate 400 mcg (Ingredients in Telomere BioSciences "Telomere Length Complex": L-Arginine, Fo-Ti Root, L-Citrulline, Rehmanna Root, Ligusticum Berry, Astralagus Root Extract, Grape seed Extract, Vit C - 540 mg, Vit D3 600 IU, Vit E 310 IU, Folate 400 mcg)

Potential study funding sources

Michael Milken Faster Cures (Noel)
Ellison Aging Institute (Noel)
David H. Murdock Research Institute (Noel)
Prostate Cancer Foundation (Noel)
Thiel Foundation (Melanie/CP)
Paul Tarini, a senior program officer at the Robert Wood Johnson Foundation (Melanie)
Templeton Foundation, Ayako Fukui, FQXi, starting genomics program (Melanie)

Immunology advisors (subject matter experts)

Protocol confirmation: Correct protocol (positive structure/function), what is missing, what would be logically measured; effect was most pronounced in CMV+ individuals
Contacts

Monica Ranes-Goldberg, Immunology Professor, UCSC (8/3, call 8/10)
Daniel Kraft, Stanford Stem Cell Research (8/3)
Mark Hamalainen, Halcyon Molecular (8/3)
Mark M Davis, Dir Stanford Inst for Immunology
Chris Hogg, Gilean (8/3, no immediate contacts)

CROs

IRB (Institutional Review Board) strategy, informed consent, regulatory concerns, ethics, etc.

Oncology contacts

Prostate cancer - Jonathan Oppenheimer www.ourlab.net, www.prostatelab.com/jrocv.htm
Breast (and ovarian?) cancer - Susan J Love Foundation representative

Protocol development

Budget

Intervention - TA-65
Testing - blood sample collection and shipping, UCLA immunology tests, TelomeHealth critically-short telomere-length testing and storage, 23andMe genotyping
Staff time - study planning, administration
Publication cost (if open-access journal selected (PLoSOne $1350, JMIR $1900)