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MTHFR_Results

Page history last edited by Administrator 3 years ago

DIYgenomics citizen science experiments - MTHFR Results

 

Back to main MTHFR study page

Back to main DIYgenomics wiki page

Contact @DIYgenomics or studies at DIYgenomics.org for more information or to participate.

 

Final study results published December 2010:

Citizen Science Genomics as a Model for Crowdsourced Preventive Medicine Research

 

A. Genotype results

 

Participant  rs1801133 Maj/Min (G/A)
rs1801131 Maj/Min (T/G)
Maternal Haplogroup Paternal Haplogroup

Ethnicity

(Eur/Asian/African)

Gender DOB Age

Vegan / Vegetarian

Status

Citizen 1 (AV) AG  TT   J1b1a R1b1b2a1a2
European
Male
5/18/1974
36 Vegan
Citizen 2 (RM)
GG  GG  K1c2 R1b1b2a1a2*
European Male 4/1/1966 44 n/a
Citizen 3 (MS)
AG  GT K1a   European Female 7/1/1978
42 Vegetarian
Citizen 4 (KH)
GG GT
 
K1b2a   
European Female 12/25/1963 47 n/a
Citizen 5 (CH)
GG
GT
 
H11a R1b1b2a1a2f2
European
Male
2/18/1975
35 n/a
Citizen 6 (TK) AG
GT
    Japanese
Male
    n/a
Citizen 7 (WR) A TT  J2a1a1  R1a1a*  European  Male  5/22/1984  26  n/a 

 

Note: Maternal and Paternal Haplogroups are not very indicative of overall ancestry, as they just pinpoint an ancestor from the purely maternal or paternal line. Also, gender can be inferred from lack of a paternal haplogroup report. Self-identified ethnicity may be a better measure.

 

B. Blood test results

 

 

Crossover Study Phases:

1 - Initial wash-out period

2 - Drug store multivitamin (Centrum) only

3 - L-methylfolate only

4 - Drug store multivitamin (Centrum) + L-methylfolate

5 - Final wash-out period

 

Other possible phases:

* "Mega-dose" multivitamin only (for example: Solgar Vegetarian Multiple)

* Personal vitamin regimen -- will differ, so not good for comparison, but may be useful for individual tracking

 

1. Homocysteine (in umol/L, reference range: 0.0 - 15.0)

Study Phase
1
Citizen 1 (AV)
12.6  9.3  11.2
15.9  14.2
Citizen 2 (RM)
6.4  9.0  7.0
7.9  8.7 
Citizen 3 (MS)
12.9  9.1  12
12.8  9.8
Citizen 4 (KH)
10.5  9.2
8.6  8.1  6.3 
Citizen 5 (CH)
14.1  10.6
15.2  n/a 18.4  
Citizen 6 (TK) 9.6 9.0 9.4
n/a n/a
Citizen 7 (WR) 6.7  5.7  8.4  n/a  n/a 

 

2. Vitamin B12 (in pg/mL, reference range: 211 - 946)

Study Phase
Citizen 1 (AV)
482  527  501
493  562
Citizen 2 (RM)
715 594 625  661  n/a 
Citizen 3 (MS)
253 329 312
318
311
Citizen 4 (KH)
n/a n/a  n/a  n/a  n/a 
Citizen 5 (CH)
185  209
186  n/a 198  

 

3. Folate (Folic Acid), Serum (in ng/mL, reference range: >3.0, indeterminate: 2.2 - 3.0; deficient: <2.2)

Study Phase
Citizen 1 (AV)
14.8  16.2  >20
>19.9  >19.9
Citizen 2 (RM)
10.4 11.9 >19.9  >19.9  n/a 
Citizen 3 (MS)
15.4 17.6 19.9
>19.9
18.3
Citizen 4 (KH)
n/a n/a  n/a  n/a  n/a 
Citizen 5 (CH)
16.3  >19.9
>19.9
n/a >19.9   

 

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